Selenium

Organic Selenium is powerful antioxidant trace mineral that increases levels of Glutathione peroxidase, a front line enzyme protecting against oxidative stress in the nervous system.

• Supplementation of organic Selenium as selenomethionine significantly increases blood and tissue levels of selenium and increases the activity of glutathione peroxidase in human subjects. Vitamin B6 is a necessary co-factor for selenomethionine to be incorporated into glutathione peroxidase.
• Selenium protects neurons against methamphetamine-induced dopaminergic neurotoxicity as a result of increased free radical activity.

Glutathione peroxidase works with SOD and catalase in a tight knit defense system. GSH-peroxidase reduces hydrogen peroxide to water. Hydrogen peroxide levels increase due to DA and MDMA metabolism. The activity of glutathione peroxidase is mediated by the availability of the mineral Selenium.

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These statements have not been evaluated by the Food and Drug Administration.

1. Smith PJ; et al. Glutathione peroxidase activity as a function of dietary selenomethionine. Nature, 247(440): 392-3, 1994
   
   
2. Robinson MF; Campbell DR Effect of daily supplements of selenium on patients with muscular complaints in Otago and Canterbury. N Z Med J. 93(683): 289-92, 1981
   
   
3. Imam SZ; et al.. Selenium, an antioxidant, protects against methamphetamine-induced dopaminergic neurotoxicity. Brain Res. 818(2): 575-8, 1999
   
   
4. Beilstein MA; Whanger PD. Glutathione peroxidase activity and chemical forms of selenium in tissues of rats given selenite or selenomethionine. J Inorg Biochem. 331(1): 31-46, 1988
   
   
5. Yasumoto K; et al. Vitamin B6 dependence of selenomethionine and selenite utilization for glutathione peroxidase in the rat. J Nutr. 109(5): 760-6, 1979