Ascorbic Acid
Ascorbic acid is a water soluble antioxidant which is distributed throughout the tissues of
the body and is concentrated in the adrenal glands and central nervous system. Approximately
80% of the total body ascorbate load is found in the brain, and specifically within nerve
terminals. Ascorbic acid is an important neuroprotective antioxidant that directly scavenges
hydroxyl and peroxyl radicals as well as superoxide radicals and singlet oxygen.
Two studies reported that large dosages of vitamin C (as injectable sodium ascorbate)
blocked neurotoxicity in rats. If one takes into account the increased clearance and
other pharmacokinetic parameters that change due to the lower body weight of the rat
compared with humans, a quantity of 2 grams of vitamin C may protect users of MDMA from
oxidative stress.
- Ascorbic acid is an important neuroprotective antioxidant that directly scavenges hydroxyl and peroxyl radicals as well as superoxide radicals and singlet oxygen.
- Two studies reported that large dosages of vitamin C (as injectable sodium ascorbate) blocked MDMA neurotoxicity in rats.*
*If one takes into account the increased clearance and other pharmacokinetic parameters that change due to
the lower body weight of the rat compared with humans, a quantity of 2 grams of vitamin C may protect
users of MDMA from oxidative stress.
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Dosage Range: 1-2 grams of vitamin C a day. Acute dosage: Up to 10g (in the form of
calcium ascorbate to minimize diarrhea )during MDMA usage. While the normal saturation dose of
Ascorbate is 250mg/day, much higher levels can be used when the system is under acute
oxidative attack. It should be taken with other antioxidants to keep it in a reduced form.
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SPECIAL ONLINE PRICE
$7.50 per bottle (100 capsules - 1000mg)
These statements have not been evaluated by the Food and Drug Administration.
References
- Majewska MD; Bell JA. Ascorbic acid protects neurons from injury induced by glutamate and NMDA. Neuroreport. 1(3-4): 194-6, 1990
- Gudelsky GA. Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin. J. Neural Transm. 103(12):1397-404, 1996.
- Shankaran M, et al. Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT. Synapse 2001 Apr;40(1):55-64
- Wilson JX. Antioxidant defense of the brain: a role for astrocytes. Can J Physiol Pharmacol. 75(10-11): 1149-63, 1977
- Grünewald RA. Ascorbic acid in the brain. Brain Res Brain Res Rev. 18(1): 123-33, 1993
- ODonnell E; Lynch MA. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol Aging, 19(5): 461-7, 1988
- Levine S; Kidd. Antioxidant Adaptation. Its Role in Free Radical Pathology. Allergy Reseach, San Leandro, CA. 1985
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