2-AEP (2-aminoethanol phosphate)

2-AEP (2-aminoethanol phosphate) aka Calcium AEP, colamine phosphate, is an essential factor for maintaining the integrity of the cellular membranes of neurons. When the salts of 2-AEP are introduced into the bloodstream they are directed to the cell membrane and integrated into the cell membrane, predominantly at the entry spots of the so-called "free lipid pore." It binds fatty acids preceding and following the peptide chains of the cell membrane structure.

Studies conducted over the last 30 years have shown that 2-AEP has important actions that maintain cell membrane integrity and protect cells from degeneration. 2-AEP performs the following actions:

  • 2-AEP facilitates transport of electrolytes and essential nutrients into cells.
  • 2-AEP shields and "seals" cell membranes from harmful agents.
  • 2-AEP maintains neurotransmission, necessary for the electrochemical communication
    between cells.
  • 2-AEP binds calcium and other minerals to cell membranes to serve as "electrical condensers"; essential for cellular regulation.
  • 2-AEP maintains the bioenergetic cell potential and helps maintain cell receptor sensitivity.

In medical clinics worldwide, 2-AEP has been utilized in the treatment of various neurodegenerative disorders. This list includes multiple sclerosis (MS) and other sclerotic disorders including amyotrophic lateral sclerosis (ALS) and progressive systemic sclerosis.

2-AEP's regulation of the transmembrane ion exchange, increasing neuronal conductivity, increasing neurotransmissions and preventing cytotoxic destruction of the lipid layer of the membranes of neurons makes 2-AEP a useful neuroprotective supplement for the user of MDMA, amphetamines and cocaine. 2-AEP may prove useful at repairing the impaired serotonergic neurotransmissions and increasing the diminished sensitivity of serotonin receptors.

Dosage Range:1-2 grams of 2-AEP/ day.

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These statements have not been evaluated by the Food and Drug Administration.


References


  1. Nieper, HA. The colamine phosphate salts as membrane integrity factor. Available from the A. Keith Brewer International Science Library.

  2. Nieper HA. Uses of CaEAP for MS, asthma & diabetes. Raum & Zeit, 1988.

  3. Morrissette G., Retrospective Study of the Effect of Ca (Mg, K) B AEP in MS Patients. Hans Nieper Archive, A. Keith Brewer Sc. Library, Richland Center, WI 53581.

  4. Nieper HA; Blumbergerger A. Electrolyte Transport Theory of Cardiovascular Diseases." electrolytes and Cardiovascular Diseases, Ed. by E. Batusz, S. Karger, Basel/New York; (2) . 141 173, 1966

  5. Rothfield L; Finkelstein A. Membrane Biochemistry. Ann. Rev. Biochem. (37) 463 491, 1968

  6. Singer SJ. The Molecular Organization of Membranes. Dept. of Biology, University of California at San Diego, 805 833. 1974

  7. Ferrari V; Harkness RD. Increase of 2-amino-ethyl-phosphate in regenerating liver tissue. Phyhsiol. 113;27, 1951

  8. Neiper, H.A, et al. A clinical study of the calcium transport substances Ca 1-d1 aspartate and Ca 2-aminoethanol phosphate as potent agents against autoimmunity and other anticytological aggressions. 2nd communication Agressologie. 1967 Sep-Oct;8(4):395-406


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